PARIS 2 Trial
Nasal High Flow Therapy for Infants and Children with Acute Hypoxemic Respiratory Failure – a Randomised Controlled Trial
This study aims to conduct a multi-centre trial to assess which infants and children with acute hypoxemic respiratory failure (AHRF) benefit from using Nasal High Flow (NHF) Therapy. For this purpose we will perform a randomised controlled trial comparing current best practice (standard oxygen delivery via subnasal prongs, facemask, venturi mask) versus NHF therapy in children aged 1 – 4 years. With the introduction of this simple to use respiratory system in regional and tertiary centres we aim to investigate if NHF therapy has a lower treatment failure rate in comparison to standard oxygen delivery, and to investigate if there is a reduction in the need for transfer of these patients the intensive care unit.
Study design
A phase III randomised controlled trial
Chief Investigator
A/Prof Andreas Schibler (Queensland Children’s Hospital)
Timeframe
2017 – 2021
Funding
Thrasher Research Funds
National Health and Medical Research Council (ID:1123663)
Children’s Health Foundation (LCCH),
Emergency Medicine Foundation
Site locations
- Lady Cilento Children’s Hospital, Brisbane, QLD, Australia
- Royal Children’s Hospital, Melbourne, Australia
- Gold Coast Hospital, Southport, Queensland, Australia.
- Starship Children’s Hospital, Auckland, New Zealand
- KidzFirst Middlemore Hospital, Auckland, New Zealand
- Redcliffe Hospital, Redcliffe, QLD, Australia
- Prince Charles Hospital, Chermside, QLD, Australia
- Sunshine Coast University Hospital, Sunshine Coast, QLD, Australia
- Logan Hospital, Logan, QLD, Australia
- Ipswich Hospital, Ipswich, QLD, Australia
- Redland Hospital, Cleveland, QLD, Australia
- Toowoomba Hospital, Toowoomba, QLD, Australia
- The Tweed hospital, Tweed Heads, NSW, Australia
- Monash Children’s Hospital, Clayton, VIC, Australia
- Townsville Hospital, Townsville, Queensland, Australia
- The Children’s Hospital at Westmead, Sydney, NSW, Australia
- Caboolture Hospital, Caboolture, QLD, Australia
- Perth Children’s Hospital, Perth, WA, Australia
- John Hunter Hospital, Newcastle, NSW, Australia
Sample
1634 children aged 1 – 4 years + 364 days with AHRF
Clinical trial registrations
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