Author: Marian Chandler

Congratulations to the following PREDICT authors:

Gc VS, Franklin D, Whitty JA, Dalziel SR, Babl FE, Schalpbach LJ, Fraser JF, Craig S, Neutze J, Oakley E, Schibler A.  First-line oxygen therapy with high-flow in bronchiolitis is not cost saving for the health service. Arch Dis Child. 2020 Apr 10. doi: 10.1136/archdischild-2019-318427. [Epub ahead of print] [link]

Congratulations to Libby Haskell, and the rest of the KT bronchiolitis team in Australia and New Zealand.  Their qualitative paper entitled “Understanding factors that contribute to variations in bronchiolitis management in acute care settings: a qualitative study in Australia and New Zealand using the Theoretical Domains Framework” has been accepted for publication in BMC Pediatrics.

 

 

Trans-nasal Humidified Rapid- Insufflation Ventilatory Exchange in Children Requiring Emergent Intubation (Kids THRIVE): A Randomised Controlled Trial

RECRUITMENT STATS

Study commenced December 15^th 2017

• >1,314 screened for KIDS THRIVE eligibility
• 548 randomised
• 503 enrolled
• 37 post randomisation exclusion
• 95 Prospective consent
• 416 Consent to continue (delayed consent)
• 140 Parental awareness of study when using delayed consent
• 5 Refused – prospective approach
• 11 Refused – Consent to continue (delayed consent)
• 0 Withdrawn
• 9 hrs Mean time taken to finalise consent to continue

Sites currently recruiting:

• QCH, Brisbane (ED & PICU) – 256 recruited
• RCH, Melbourne (PICU) – 111 recruited
• RCH, Melbourne (NICU) – 21 recruited
• GCUH, Qld (ED & PICU) – 34 recruited
• PCH, WA PICU – 13 recruited
• Monash Health – 5 recruited (ED& PICU)
• Townsville (ED & PICU) – 25 recruited
• Women’s and Children’s, Adelaide (PICU) – 12 recruited
• Westmead Children’s Hospital, Sydney (PICU) – 24 recruited
• Starship Children’s Hospital, New Zealand (ED & PICU) – 2 recruited [site paused due to issues with delayed consent]

Sites to commence recruiting in 2020:

• BC Children’s Hospital, Vancouver, Canada
• University Kinderspital Zurich Children’s Hospital, Zurich
• Vittore Buzzi, Milan, Italy

News:

The KIDS THRIVE study has recruited 503 patients with WCH PICU in Adelaide recruiting the 500^th patient to this trial at the end of April 2020. Recruitment has been a bit slower since the Covid 19 crisis due to reduced surgical lists and our PICU’s and ED’s being quieter.

The KIDS THRIVE Steering Committee is working hard in the background to finalise the data cleaning process for all patients and aims to commence this shortly.

This trial is exceptional, and we thank the huge effort that all sites continue to put in to making this study successful and demonstrating that research can be done in critically ill children in the emergency setting when we all work together.

Thank you!

 

Congratulations to Donna, Andreas and the team – the PARIS STUDY IS COMPLETE!

A total of 1514 patients were enrolled with the end point being reached in 15 months – no small feat at all.

This has been a huge effort from everyone involved with contributions from 14 hospitals in both ED and general paediatrics.

The aim now is for another NEJM if possible.  That would be the icing on the cake!

 

 

 

 

 

 

 

Our “Getting to Know You” segment ensures PREDICT members are aware of new members, their interests and areas of expertise and where they are located.

This month we introduce Professor Sandy Middleton from the Nursing Research Institute (NRI).

“I am the Director of the Nursing Research Institute (NRI), a collaboration between St Vincent’s Health Network Sydney, St Vincent’s Hospital Melbourne and Australian Catholic University. Our team conducts rigorous multidisciplinary clinical and health services research focused on improving patient outcomes and health systems.

I have a particular interest in implementation science research examining ways to promote evidence translation in the areas of stroke management, hospital-acquired complications and patient safety. I am one of the chief investigators in the NHMRC Paediatric Emergency Medicine Centre for Research Excellence leading the implementation science research projects.”

 

Dear PREDICT members,

We hope that you are staying well amidst the craziness of the ever changing COVID 19 situation.

The PREDICT Executive have discussed the effects of COVID 19 situation at length in view of our research program. Clearly this will have a significant impact on individual site’s capacity and our research activities overall. Some research projects may need to halt certain activities or delay commencement whilst others may be able to progress preparatory work etc.

Please wait to be advised by the individual project lead for advice and or direct specific questions to the appropriate project lead.

Please also see below a link to NHMRC grant advice.

NHMRC released advice regarding grant administration matters

We are currently reviewing this along with information from our own grants department.

Stay safe.

Congratulations to the following PREDICT authors:

Haeusler GM, Thursky KA, Slavin MA, Babl FE, De Abreu Lourenco R, Allaway Z, Mechinaud F, Phillips R; Australian PICNICC study group and the PREDICT network. Risk stratification in children with cancer and febrile neutropenia: A national, prospective, multicentre validation of nine clinical decision rules. EClinicalMedicine. 2020 Jan 7;18:100220. doi: 10.1016/j.eclinm.2019.11.013. eCollection 2020 Jan.

Haeusler GM, Thursky KA, Slavin MA, Babl FE, De Abreu Lourenco R, Allaway Z, Mechinaud F, Phillips R; Australian PICNICC study group and the PREDICT network.EClinicalMedicine.
Risk stratification in children with cancer and febrile neutropenia: A national, prospective, multicentre validation of nine clinical decision rules. EClinicalMedicine. 2020 Jan 7;18:100220. doi: 10.1016/j.eclinm.2019.11.013. eCollection 2020 Jan

Hopper SM1,2,3, McKenna S1,2, Williams A1,2, Phillips N4,5, Babl FE1,2,3; Paediatric Research in Emergency Departments International Collaborative (PREDICT). Clinical clearance and imaging for possible cervical spine injury in children in the emergency department: A retrospective cohort study. Emerg Med Australas. 2020 Feb;32(1):93-99. doi: 10.1111/1742-6723.13351. Published.

Kochar A, Borland ML, Phillips‍‍ N, Dalton S, Cheek JA, Furyk ‍J, Neutze J, Lyttle MD, Hearps S, Dalziel S, Bressan ‍S, Oakley E, Babl ‍FE. Association of clinically important traumatic brain
injury and Glasgow Coma Scale scores in children with head injury. Emerg Med J. 2020, Feb 12. doi: 10.1136/emermed-2018-208154. [Epub ahead of print].

Singh S, Hearps SJC, Borland ML, Dalziel SR, Neutze J, Donath S, Cheek JA, Kochar A, Gilhotra Y, Phillips N, Williams A, Lyttle MD, Bressan S, Hoch JS, Oakley E, Holmes JF, Kuppermann N, Babl FE; Paediatric Research in Emergency Departments International Collaborative (PREDICT). The Effect of Patient Observation on Cranial Computed Tomography Rates in Children with Minor Head Trauma.  Acad Emerg Med. 2020 Feb 16. doi: 10.1111/acem.13942. [Epub ahead of print].

The PREDICT members meeting will be held on October 28th 2020 at RCH, preceding the PAC/APLS conference which will be held in Melbourne at the Pullman on the Park in East Melbourne.

DATE: Wednesday 28/10/20 (one day only this year)

TIME: 9.30am – 5.30pm (followed by PREDICT dinner – details TBC)

VENUE: Royal Children’s Hospital, Vernon Collins meeting room

Further details including registration process will be available mid-May.  This meeting has been forwarded as a calendar invite.  Please check that it is in your diary.

See 2020 meeting schedule here.

All PREDICT endorsed research that is published needs to conform with our approved Guidelines so please ensure you read our updated guidelines now.

Key points we wish to bring to your attention are:

• Please read the “Requirements for authorship”  – which provides guidance on how to make authorship decisions when there are large groups of potential authors.
  A new planning template and example is provided.
• Please ensure you acknowledge the Centre for Research Excellence grant using the wording noted in the guidelines.
• All PREDICT publications must be reviewed by the Chair of PREDICT prior to submission to a journal.
  Please allow approximately 2 weeks for your draft to be reviewed and email Meredith.borland@health.wa.gov.au directly.
• Contributors  who do not meet the criteria for authorship but who have contributed to the study should be acknowledged.
• Please remember to acknowledge all funding groups appropriately and invite them to use a prepared media release if available/relevant.

The January 2020 newsletter for the PERN Pneumonia study can be found here.