Just a reminder that to attend the annual PREDICT members meeting this year in Hobart, participants must be PREDICT members.
If you are not a member and wish to become one, please email Marian (marian.chandler@mcri.edu.au) or Cate (catherine.wilson@mcri.edu.au) for a link to the membership application form.
Congratulations to the authors of the following PREDICT publications, which are now available:
O’Brien S, Wilson S, Gill FJ, Cotterell E, Borland ML, Oakley E, Dalziel SR; Paediatric Research in Emergency Departments International Collaborative (PREDICT) network, Australasia. The management of children with bronchiolitis in the Australasian hospital setting: development of a clinical practice guideline. BMC Med Res Methodol. 2018 Feb 12;18(1):22. doi: 10.1186/s12874-018-0478-x. [link]
Long E, Duke T, Oakley E, O’Brien A, Sheridan B, Babl FE; Paediatric Research in Emergency Departments International Collaborative (PREDICT). Does respiratory variation of inferior vena cava diameter predict fluid responsiveness in spontaneously ventilating children with sepsis. Emerg Med Australas. 2018 Mar 8. doi: 10.1111/1742-6723.12948. [Epub ahead of print] [link]
Long E, Babl FE, Oakley E, Sheridan B, Duke T; Pediatric Research in Emergency Departments International Collaborative (PREDICT). Cardiac Index Changes With Fluid Bolus Therapy in Children With Sepsis-An Observational Study. Pediatr Crit Care Med. 2018 Mar 10. doi: 10.1097/PCC.0000000000001534. [Epub ahead of print] [link].
Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, Furyk J, Fraser JF, Jones M, Whitty JA, Dalziel SR, Schibler A. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. N Engl J Med. 2018 Mar 22;378(12):1121-1131. doi: 10.1056/NEJMoa1714855. [link].
Elliot Long, Ed Oakley, Franz E. Babl; Department of Emergency Medicine,The Royal Children’s Hospital and Murdoch Childrens Research Institute,Parkville, Victoria, Australia. “The Clinical Utility of Respiratory Variation in Inferior Vena Cava Diameter for Predicting Fluid Responsiveness in Spontaneously Ventilating Patients” SHOCK VOL. 49, No. 2. (letter to the Editor)
New PREDICT research has shown that high flow oxygen therapy via nasal cannula can be safely delivered in emergency departments and general paediatrics wards in both large tertiary children’s hospitals and smaller regional centres. The outcome of the study showed that high flow therapy compared to standard oxygen therapy reduced the need for higher level of care from 23% to 12%.
The study, “A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis“, published in the prestigious New England Journal of Medicine, involved 17 hospitals across Australia and New Zealand, including researchers from PREDICT sites: Lady Cilento Children’s Hospital & the Paediatric Critical Care Research Group (PCCRG), Brisbane; Murdoch Children’s Research Institute & the Royal Children’s Hospital, Melbourne; Monash Medical Centre, Clayton; Gold Coast University Hospital; Townsville Hospital; The Canberra Hospital, ACT; Starship Children’s Hospital and KidzFirst Middlemore, Auckland, New Zealand. This collaboration makes it the largest paediatric study in this field worldwide.
Bronchiolitis is a common viral lung disease in infants with symptoms including cough, runny nose, difficulty breathing and poor feeding. Prior studies using different medications and other interventions have not seen any significant change in outcome or burden on the health care system.
Nasal high-flow therapy is a simple and easy to use oxygen therapy that works by delivering a higher volume of air and oxygen into the nasal passage than standard oxygen delivery methods. This results in an improvement in the work of breathing of infants with bronchiolitis.
The study involved 1472 patients under 12 months old with bronchiolitis. Infants were randomised 50/50 to one treatment arm and followed throughout their admission. The study compared two oxygen therapies: standard oxygen therapy via nasal cannula and high flow therapy via nasal cannula where a higher volume of air and oxygen is delivered into the nasal passages and results in more efficient delivery of oxygen to the airways and reduces the work of breathing.
The finding from this study could change standard practice in hospitals caring for infants with bronchiolitis worldwide.
The study was funded by the National Medical Health Research Council (NHMRC), the Emergency Medical Foundation, the Mater Foundation and local hospital Foundations.
As well as the list of original “Foundation” PREDICT sites on the “About Us” page on the PREDICT website, we have now added a list of the recent “non-foundation sites.” This may be helpful to look at when considering sites for future research projects.
The PICNICC study achieved target recruitment 31/01/2018 and has now closed to accrual, with 854 Febrile Neutropenia (FN) episodes captured in our database.
No significant issues with processes, eCRF, or site recruitment.
The rate of recruitment exceeded our expectations and we are very pleased to have achieved our target sample size for PICNICC Objective 1 ahead of schedule. Pilot analysis of Objective 2 blood sampling is due to take place in February/March 2018. Data cleaning is well underway nationally and we aim to start analysing results from the study in March/April.
We have a very thorough eCRF and if anyone is interested in exploring a specific area of fever and neutropenia please do not hesitate to contact zoe.allaway@rch.org.au, or gabrielle.hauesler@petermac.org to discuss further. Thank you to all those involved in the PICNICC study for your hard work and enthusiasm!
….. Next month we feature Asthma Retrospective.
We will again be aligning the PREDICT October Executive and Members meetings with the Paediatric Acute Care (PAC) Conference 2018.
The PAC Conference will be held at Wrest Point, Hobart, Tasmania from 25th-27th October 2018. We have scheduled our executive and members face to face meetings in the days preceding the event and at the same venue. Details as follows:
23/10/18 – Executive Meeting
24/10/18 – Members meeting (full day)
25/10/18 – Members Meeting (1/2 day)
More information regarding registration and travel/accommodation bookings will be forwarded later in the year.
The following PREDICT publications are now available:
Daverio M, Babl FE, Barker R, Gregori D, Da Dalt L, Bressanon S on behalf of Paediatric Research in Emergency Departments International Collaborative (PREDICT). Helmet use in preventing acute concussive symptoms in recreational vehicle related head trauma. Brain Injury. 2018 32(3):335-341. doi: 10.1080/02699052.2018.1426107. Epub 2018 Jan 22. [link].
Crowe LM, Hearps S, Anderson V, Borland M, Phillips N, Kochar A, Dalton S, Cheek JA, Gilhotra Y, Furyk J, Neutze J, Lyttle MD, Bressan S, Donath S, Molesworth C, Oakley E, Dalziel SR, Babl FE. Investigating the variability in mild traumatic brain injury definitions: a prospective cohort study. Arch Phys Med Rehabil. 2018 Jan 30. pii: S0003-9993(18)30042-X. doi: 10.1016/j.apmr.2017.12.026. [Epub ahead of print] [link].
Babl FE, Oakley E, Dalziel SR, Borland ML, Phillips N, Kochar A, Dalton S, Cheek JA, Gilhotra Y, Furyk J, Neutze J, Donath S, Hearps S, Molesworth C, Crowe L, Bressan S, Lyttle MD. Accuracy of Clinician Practice Compared With Three Head Injury Decision Rules in Children: A Prospective Cohort Study. Ann Emerg Med. 2018 Feb 13. pii: S0196-0644(18)30028-3. doi: 10.1016/j.annemergmed.2018.01.015. [Epub ahead of print] [link].
Furyk J., Ray R., Watt K., Dalziel S. R., Oakely E., Mackay M., Dabscheck G., Riney K., and Babl F. E., Consensus Research Priorities for Paediatric Status Epilepticus: A Delphi Study of Health Consumers, Researchers and Clinicians. Seizure, (2018) 56 104-09. [link]
A reminder that any new projects you may wish to conduct with PREDICT network involvement should firstly be submitted to the PREDICT executive team for review, advice and endorsement. Information to support new project applications is available under the research resources tab on the PREDICT website.
We look forward to hearing from you.
A reminder that any new projects you may wish to conduct with PREDICT network involvement should firstly be submitted to the PREDICT executive team for review, advice and endorsement. Information to support new project applications is available under the research resources tab on the PREDICT website.
We look forward to hearing from you.
Congratulations to Cate Wilson and Franz Babl for their successful application on behalf of APHIRST-Gap to participate in the Advancing Knowledge Translation and Research Impact project with the Centre for Community Child Health. $20,000 was awarded for 2018-19 and will be used to fund KT-focused initiatives
