Author: Marian Chandler

Each month we feature photos of a research team at one of our sites to help put faces to the names we frequently email. This month meet some of the team at Princess Margaret Hospital for Children in Perth.  We also have some pics of the new hospital which look quite amazing!

Congratulations to Franz and Ali for their successful application for funding from The Angior Family Foundation.  A grant for $23,700 has been awarded for their project “Australian Paediatric Head Injury Rules Prior to Implementation” (A-GAP). This research aims to optimise health outcomes for children presenting to emergency with head injuries through minimising unnecessary exposure to damaging radiation from CT scanning.

 

 

Congratulations to Susan Montgomery for her successful funding application for the PREDICT KT study.  A grant of $18,323 has been awarded by the Townsville Hospital & Health Service Research Trust Fund.

Congratulations to Stuart Dalziel who has been awarded a $5m program grant from the Health Research Council of New Zealand (HRC) to study the link between paracetamol and childhood asthma.  See press release.

 

 

Registration for the PREDICT members meeting on 25th & 26th October is NOW OPEN via Trybooking.  As previously advised, registration had to be made by 30/6/17 to be considered for a sponsored position (funding of travel and accommodation to attend). However, you must still register if you will be attending the event by your own means.

Our special guest for this meeting is Dr Terry Klassen, a clinician-scientist in Pediatric Emergency Medicine and Head of the Department of Pediatrics and Child Health, University of Manitoba (U of M).  Terry is a co-founder of PERC (Pediatric Emergency Research of Canada), and has a consistent record of national and international peer-reviewed funding, along with a publication records that include many articles in the highest impact medical journals. In 2009, Dr. Klassen founded PERN, Pediatric Emergency Research Networks; the umbrella group for the six pediatric emergency medicine research groups.

We hope you can join us on the Gold Coast in October.

Enrolment

PARIS 1 completed enrolment 18 months ahead of schedule – August 15^th 2016.

Recruitment stats

• 1472 total recruitment
• 179 excluded (who met inclusion criteria)
• 77 ineligible
• 84 declined consent (prospective and delayed)
• 20 revoked
• 566 (26.6%) Total eligible, screened missed patients

Trial stopped fully on 15^th August 2016

Adverse events – 2 x pneumothorax (one in each treatment arm)

NEWS:
Currently data has been cleaned and draft paper is being circulated prior to submitting to the NEJM

PARIS 2- pilot – just completed
PARIS 2 – RCT – just started

 

Ethics and governance:

Queensland sites have ethics approval. A multi-site NEAF has been prepared for Victoria, SA, NSW and ACT sites, and is currently under review at Monash Health. Tasmania, Darwin and NZ have also made ethics applications.

A data-sharing agreement will also need to be arranged and must be signed off at all sites before data collection can commence. This is currently being reviewed by Monash Health and MCRI.

Other progress:

• REDCAP database has been constructed and tested.
• Funding applications have been submitted, no successful applications yet.

International (PREDICT-led) Asthma Projects:

An international working group, with representatives from all PERN research networks has been formed to look at outcome measures in clinical trials of acute severe paediatric asthma. A number of projects are being planned, and will be circulated through PREDICT as they develop.  It is likely that future asthma work will include:

• Interviews and/or surveys with clinicians
• Interviews and/or surveys with patients
• Review of clinical guidelines
• ICU registry data
• Ambulance data
• Validation of clinical asthma severity scores
• Prioritisation of outcome measures
• Development of consensus documents regarding the conduct and reporting of clinical trials in acute severe asthma.

Please contact Simon (simon.craig@monashhealth.org) with any queries.

Each month we feature photos of a research team at one of our sites to help put faces to the names we frequently email.  This month meet the team at John Hunter Hospital.

 

The following PREDICT publications are now available:

Long E, Oakley E, Duke T, Babl FE; Paediatric Research in Emergency Departments International Collaborative (PREDICT).
Does Respiratory Variation in Inferior Vena Cava Diameter Predict Fluid Responsiveness: A Systematic Review and Meta-Analysis. Shock. 2017 May;47(5):550-559. doi: 10.1097/SHK.0000000000000801. PMID: 28410544 Link

Oakley E, Chong V, Borland M, Neutze J, Phillips N, Krieser D, Dalziel S, Davidson A, Donath S, Jachno K, South M, Fry A, Babl FE.
Intensive care unit admissions and ventilation support in infants with bronchiolitis. Emerg Med Australas. 2017 May 19. doi: 10.1111/1742-6723.12778. [Epub ahead of print] PMID: 28544539 Link

The PREDICT Prize in Paediatric Emergency Medicine (PREDICT Prize) will be presented at the 2017 ACEM Annual Scientific Meeting (ASM) being held 19 – 23 November in Sydney.

The Paediatric Research in Emergency Medicine Departments International Collaborative (PREDICT), will award $500 cash for the best paper that addresses an important topic in Paediatric Emergency Medicine.  Abstracts will be reviewed by the PREDICT panel and the selected abstracts will be advised and adjudicated during the ASM based on selected criteria.

Abstract submissions close on 14/6/2017.

To be eligible for the PREDICT award the following criteria applies:

• Applicants must be trainee, medical student, or from allied health professions at the time of the presentation
  Research involves children < 17 years and performed primarily in an emergency department setting in Australia and or New Zealand

See http://acem2017.com/abstract-awards/  for further criteria.